Even if the term isn’t trademarked, don’t buy domains that are just a variation of another domain name. This means avoiding plurals if the singular is taken (mediatemple.net vs. mediatemples.net), hyphenating a phrase (media-temple.net), or adding “my” or some other preposition (mymediatemple.net). Alternately, you might consider buying these variations yourself and set them up so that if someone types one of the variations, they are redirected to your main site.
Think of the name you want to register. The answer is typically your company or website name. It is best to keep your domain name short and easy to understand. Say it out loud, and make sure it sounds great. Next, search to see if it is available. If the name you desire is taken with the .com top-level domain, there are hundreds of others available. Finally, add the top choices to your cart and complete the domain registration.
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You should also avoid words that have more than one spelling if your visitors are likely to be confused and mistype the name. Alternately, you can buy both versions of the name and direct visitors from the one you like less to the preferred name. While you do want a short name (see below), don’t go for something so cryptic that people have a hard time remembering it. Word of mouth is a powerful marketing tool and you want to make it easy for people to tell their friends about your site.
When looking up a bare name in DNS, the network stack will add the search domains to it to form fully qualified domain names, and look up those as well. For example, if the domain search list contains "wikipedia.org", typing "en" in the browser will direct the user to "en.wikipedia.org". Some ISPs add their own search domains via DHCP settings, similar to how they add DNS servers and other networking information; if this is undesired, the user can change this setting to ".local".