Even if the term isn’t trademarked, don’t buy domains that are just a variation of another domain name. This means avoiding plurals if the singular is taken (mediatemple.net vs. mediatemples.net), hyphenating a phrase (media-temple.net), or adding “my” or some other preposition (mymediatemple.net). Alternately, you might consider buying these variations yourself and set them up so that if someone types one of the variations, they are redirected to your main site.
Make sure you always retain control of your domain name. There are hundreds of businesses hosting their websites with a web host they’re not happy with. Poor service, surprise invoices, unreliable uptime and email issues are just some of the common issues customers are facing today. What most of them want to do is vote with their feet and walk out the door and find another web hosting provider. They don’t go through with it, however, because moving all their domains to another host is a complete admin headache. Choose wisely from the get-go so you don’t become one of these customers.
You should also avoid words that have more than one spelling if your visitors are likely to be confused and mistype the name. Alternately, you can buy both versions of the name and direct visitors from the one you like less to the preferred name. While you do want a short name (see below), don’t go for something so cryptic that people have a hard time remembering it. Word of mouth is a powerful marketing tool and you want to make it easy for people to tell their friends about your site.
By definition, a domain name is simply a human readable form of an IP address. In function it is the destination that you type into a web browser in order to visit a website, such a www.google.com. Metaphorically, it is very similar to how you would scroll to a contact in your cell phone rather than manually dialing the person by entering their full phone number; the phone number would be an IP address and the saved contact would be a domain name. Always buy a domain with a reputable domain registrar.