The Internet Corporation for Assigned Names and Numbers (ICANN) is the organization that governs the rules and regulations for domain name registrations. ICANN requires, for various reasons including to determine ownership of a domain should a dispute transpire, that a publicly accessible database be maintained that contains the contact information of all domain registrants. In layman's terms this means your domain name will be searchable by anyone and those search results will include your full name, physical address and other contact information. In order to protect your privacy in this regard, Domain.com offers WHOIS Domain Privacy which then masks your information using our own and implements a procedure for you to control who is able to then gain access to your contact information via a WHOIS search. Whenever you buy a domain name, no matter what domain name registration service you use, you are subject to the same ICANN rules, for this reason it is important to use a reputable service who cares about your privacy. Domain.com always recommends enabling WHOIS Domain Privacy.
Most people assume a domain name ends in .com so if you buy a domain name with one of the other extensions (.net, .info, .org, etc.), you’ll have some extra work to get people to remember that your site has a different extension. Don’t automatically assume you should only buy domains with .com, though. Many sites have done quite well with other extensions. (Look at us!)
Avoid having numbers in your domain name. People can get confused about whether the numbers is a digit (3) or a word (three). If you want a number in your domain name because there’s a number in your company name, buy both versions (digit and word) and redirect one to the other. Be especially wary about using the number “0” in a domain name as people may see it as the letter “O.”
Check to see if you get any email accounts. Many web hosting companies don’t include email or charge extra for it. In many cases, you can only get email forwarding. Even for straightforward POP3 email, some companies only offer 1 or 2 email accounts. You should make sure you get at least 15-20 POP3 email accounts included free of charge with your domain.
Check to see if you get any email accounts. Many web hosting companies don’t include email or charge extra for it. In many cases, you can only get email forwarding. Even for straightforward POP3 email, some companies only offer 1 or 2 email accounts. You should make sure you get at least 15-20 POP3 email accounts included free of charge with your domain. 

Many online shops have the number 24 in them, to signify 24 hours a day – you may also be able to integrate numbers into your domain in a meaningful way to make them unique. Be careful though, because many cultures attach a lot of significance to certain numbers. Make sure that your number doesn't represent bad luck or other negative things in the country you're operating in.
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