The longer your domain name is, the harder it is for people to remember it and the more chance you have of someone misspelling one of the words. Most good single word domain names are long gone, but you can still avoid long domain names by getting a little creative. If you have a single word you really like that is not available, try adding an adjective or verb in front of it and seeing if those variations are available. Think of your domain name as part of your brand, and make sure it matches how you want people to think of you.
Even if the term isn’t trademarked, don’t buy domains that are just a variation of another domain name. This means avoiding plurals if the singular is taken (mediatemple.net vs. mediatemples.net), hyphenating a phrase (media-temple.net), or adding “my” or some other preposition (mymediatemple.net). Alternately, you might consider buying these variations yourself and set them up so that if someone types one of the variations, they are redirected to your main site.
Many online shops have the number 24 in them, to signify 24 hours a day – you may also be able to integrate numbers into your domain in a meaningful way to make them unique. Be careful though, because many cultures attach a lot of significance to certain numbers. Make sure that your number doesn't represent bad luck or other negative things in the country you're operating in.