Check to see if you get any email accounts. Many web hosting companies don’t include email or charge extra for it. In many cases, you can only get email forwarding. Even for straightforward POP3 email, some companies only offer 1 or 2 email accounts. You should make sure you get at least 15-20 POP3 email accounts included free of charge with your domain.
Contact the owner. Before so much as hinting at a price, simply email to ask whether or not the domain is for sale. If you are known or can clearly be linked to a thriving business, create a generic alternate email address through which to contact them, as your success might be leveraged against you. Be aware, however, that an informal-sounding email address is more likely to be regarded as spam or junk mail.
Make sure you always retain control of your domain name. There are hundreds of businesses hosting their websites with a web host they’re not happy with. Poor service, surprise invoices, unreliable uptime and email issues are just some of the common issues customers are facing today. What most of them want to do is vote with their feet and walk out the door and find another web hosting provider. They don’t go through with it, however, because moving all their domains to another host is a complete admin headache. Choose wisely from the get-go so you don’t become one of these customers.
Many online shops have the number 24 in them, to signify 24 hours a day – you may also be able to integrate numbers into your domain in a meaningful way to make them unique. Be careful though, because many cultures attach a lot of significance to certain numbers. Make sure that your number doesn't represent bad luck or other negative things in the country you're operating in.