The longer your domain name is, the harder it is for people to remember it and the more chance you have of someone misspelling one of the words. Most good single word domain names are long gone, but you can still avoid long domain names by getting a little creative. If you have a single word you really like that is not available, try adding an adjective or verb in front of it and seeing if those variations are available. Think of your domain name as part of your brand, and make sure it matches how you want people to think of you.
Make sure you always retain control of your domain name. There are hundreds of businesses hosting their websites with a web host they’re not happy with. Poor service, surprise invoices, unreliable uptime and email issues are just some of the common issues customers are facing today. What most of them want to do is vote with their feet and walk out the door and find another web hosting provider. They don’t go through with it, however, because moving all their domains to another host is a complete admin headache. Choose wisely from the get-go so you don’t become one of these customers.
Most people assume a domain name ends in .com so if you buy a domain name with one of the other extensions (.net, .info, .org, etc.), you’ll have some extra work to get people to remember that your site has a different extension. Don’t automatically assume you should only buy domains with .com, though. Many sites have done quite well with other extensions. (Look at us!)
Many online shops have the number 24 in them, to signify 24 hours a day – you may also be able to integrate numbers into your domain in a meaningful way to make them unique. Be careful though, because many cultures attach a lot of significance to certain numbers. Make sure that your number doesn't represent bad luck or other negative things in the country you're operating in.
If your purpose in buying a trademarked term as a domain name is to try to confuse people, you’re opening yourself up to having a complaint filed against you and having to give up the domain name. Even if you’re not trying to create confusion, you’re likely to face some legal challenges by buying trademarked terms in your domain name. To be safe, you can search for U.S. trademarks at www.uspto.gov and make sure no one owns a trademark on the name you are considering.