Most people assume a domain name ends in .com so if you buy a domain name with one of the other extensions (.net, .info, .org, etc.), you’ll have some extra work to get people to remember that your site has a different extension. Don’t automatically assume you should only buy domains with .com, though. Many sites have done quite well with other extensions. (Look at us!)
^ Mockapetris, P.V. (November 1987). "Domain names - concepts and facilities" (HTML). IETF Documents. IETF. doi:10.17487/RFC1034. Retrieved 24 July 2017. Relative names are either taken relative to a well known origin, or to a list of domains used as a search list. Relative names appear mostly at the user interface, where their interpretation varies from implementation to implementation, and in master files, where they are relative to a single origin domain name. The most common interpretation uses the root "." as either the single origin or as one of the members of the search list, so a multi-label relative name is often one where the trailing dot has been omitted to save typing.
Even if the term isn’t trademarked, don’t buy domains that are just a variation of another domain name. This means avoiding plurals if the singular is taken (mediatemple.net vs. mediatemples.net), hyphenating a phrase (media-temple.net), or adding “my” or some other preposition (mymediatemple.net). Alternately, you might consider buying these variations yourself and set them up so that if someone types one of the variations, they are redirected to your main site.